B8562
BD 1047 dihydrobromide
≥95% (HPLC)
Synonym(s):
BD 1047 dihydrobromide
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | € 110,00 |
25 mg | Check Cart for Availability | € 433,00 € 368,05 |
About This Item
Empirical Formula (Hill Notation):
C13H20Cl2N2 · 2 HBr
CAS Number:
Molecular Weight:
437.04
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
H2O: >5 mg/mL
storage temp.
2-8°C
SMILES string
Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1
InChI
1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H
InChI key
WOALTFHGLDVJHK-UHFFFAOYSA-N
Application
BD 1047 dihydrobromide has been used as an antagonist of sigma-1 receptor in hepatocellular carcinoma cells.[1]
BD 1047, a selective, putative σ1 receptor antagonist, is used in sigma receptor research to help differentiate and characterized the function and role of the sigma1 receptor versus other sigma receptor subtypes. BD 1047 is used to help define the role of σ1 receptors in neurological processes.
Biochem/physiol Actions
BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity.
BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity. BD-1047 has >50-fold selectivity at σ1 over σ2 and also >100-fold selectivity over opiate, phencyclidine, muscarinic, dopamine, α1- & α2-adrenoceptor, 5-HT1, and 5-HT2. Though s receptor antagonism is consistent with antipsychotic, especially anti-schizophrenic, activity, BD-1047 shows only modest activity in animal screens for antipsychotics.
In human immunodeficiency (HIV)-1 seropositive patients, BD 1047 along with other antioxidants may aid in reduction of cathepsin B- based neuropathology.[2]
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) |
| form powder | form solid | form powder | form powder |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
| storage condition desiccated | storage condition - | storage condition - | storage condition desiccated |
| solubility H2O: >5 mg/mL | solubility H2O: soluble ~10 mg/mL at 60 °C (Sonicate), DMSO: soluble 12 mg/mL | solubility H2O: 20 mg/mL, clear | solubility H2O: 10 mg/mL, clear |
![cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide ≥98% (HPLC), solid](/deepweb/assets/sigmaaldrich/product/structures/255/210/7ae0c9f3-835e-4c95-aa84-bb7695fe11ac/640/7ae0c9f3-835e-4c95-aa84-bb7695fe11ac.png)
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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