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B157

BQ-788

≥95%, endothelin-B (ETRB) blocker, solid

Synonym(s):

2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle, N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt

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Pack SizeSKUAvailabilityPrice
200 μg
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€ 228,00

About This Item

Empirical Formula (Hill Notation):
C34H50N5NaO7
CAS Number:
156161-89-6
Molecular Weight:
663.78
UNSPSC Code:
12352200
PubChem Substance ID:
329773192
NACRES:
NA.32
MDL number:
MFCD00797882
Assay:
≥95%
Form:
solid
Quality level:
200

€ 228,00

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Product Name

BQ-788, ≥95%, solid

Quality Level

200

assay

≥95%

form

solid

color

white

solubility

acetonitrile: 0.3 mg/mL, DMSO: 1.2 mg/mL, ethanol: 1.2 mg/mL, H2O: slightly soluble

storage temp.

−20°C

SMILES string

[Na+].CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N3[C@@H](C)CCC[C@H]3C)C([O-])=O

InChI

1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1

InChI key

QCVIFBRTTLMEOV-FUKQNADPSA-M

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1 of 1

This Item
B150E5411L9167
BQ-788 ≥95%, solid

Sigma-Aldrich

B157

BQ-788

BQ-123 ≥99%, sodium salt, lyophilized powder

Sigma-Aldrich

B150

BQ-123

Enniatin B from Gnomonia errabunda, ≥95% (HPLC)

Sigma-Aldrich

E5411

Enniatin B

LWH-63 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

L9167

LWH-63 hydrochloride

form

solid

form

lyophilized powder

form

-

form

solid

assay

≥95%

assay

≥99%

assay

≥95% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

acetonitrile: 0.3 mg/mL, ethanol: 1.2 mg/mL, DMSO: 1.2 mg/mL, H2O: slightly soluble

solubility

-

solubility

DMSO: 10 mg/mL, ethanol: 10 mg/mL, methanol: 10 mg/mL

solubility

DMSO: ~10 mg/mL, H2O: insoluble

color

white

color

-

color

-

color

light brown

Application

BQ-788 has been used as a selective endothelin-B (ETRB) blocker in human airway smooth muscle cells (HASMCs),[1] uterine mesothelial cells (UtMCs)-derived vascular smooth muscle cells (VSMCs),[2] and human umbilical vein endothelial cells (HUVECs)[3]

Biochem/physiol Actions

Selective ETB endothelin receptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000519739
0000519739
0000496221
0000496221
0000488460

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Ovidiu Constantin Baltatu et al.
Frontiers in physiology, 3, 103-103 (2012-04-25)
Several clinical studies have investigated the potential benefits of endothelin receptor antagonism in chronic pathologies such as diabetic kidney disease. However, fluid retention and edema have been identified as major side effects of endothelin receptor antagonists. In the present study
Takeshi Nakahara et al.
Scientific reports, 10(1), 9510-9510 (2020-06-13)
Endothelin-1 (ET-1) is well known as the most potent vasoconstrictor, and can evoke histamine-independent pruritus. Recently, its involvement in cutaneous inflammation has begun to draw attention. The upregulation of ET-1 expression in the epidermis of human psoriasis patients has been
Emilie Hitzerd et al.
Hypertension (Dallas, Tex. : 1979), 75(3), 877-884 (2019-12-31)
Increasing evidence suggests a role for the ET (endothelin) system in preeclampsia. Hence, blocking this system with endothelin receptor antagonists (ERAs) could be a therapeutic strategy. Yet, clinical studies are lacking due to possible teratogenic effects of ERAs. In this
Emilia Kansanen et al.
Molecular pharmacology, 92(4), 481-490 (2017-08-06)
Nitro-fatty acids are reactive signaling mediators that are formed when unsaturated fatty acids react with nitric oxide or nitric oxide-derived species. Nitro-fatty acids can modify specific signaling pathways via post-translational modifications of Cys residues in key regulatory proteins. One of
Christian Claude Lachaud et al.
PloS one, 8(2), e55181-e55181 (2013-02-14)
In mammalian visceral organs, vascular smooth muscle cells (VSMCs) originate from an epithelial-to-mesenchymal transition (EMT) of embryonic mesothelial cells (MCs). The ability of adult MCs to recapitulate EMT and to acquire smooth muscle (SM) markers upon provasculogenic culture suggested they
View All Related Papers

Global Trade Item Number

SKUGTIN
B157-200UG04061833426203

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