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DL-2-Amino-5-phosphonopentanoic acid

Name: <SC>DL</SC>-2-Amino-5-phosphonopentanoic acid
Brand: SIGMA
Price: 157 EUR

≥98% (TLC), solid, NMDA receptor antagonist

Synonym(s):

5-Phosphono-DL-norvaline, DL-2-Amino-5-phosphonovaleric acid, AP-5, APV

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Size/SKU	Availability	Price
10 mg	Check Cart for Availability	€ 157,00
25 mg	Check Cart for Availability	€ 253,00
50 mg	Check Cart for Availability	€ 410,00
100 mg	Check Cart for Availability	€ 760,00

About This Item

Empirical Formula (Hill Notation):

C₅H₁₂NO₅P

CAS Number:

76326-31-3

Molecular Weight:

197.13

NACRES:

NA.32

PubChem Substance ID:

24277950

UNSPSC Code:

12352106

MDL number:

MFCD00010515

Beilstein/REAXYS Number:

2446389

Form:

solid

€ 157,00

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Properties

Product Name

DL-2-Amino-5-phosphonopentanoic acid, solid

form

solid

Quality Segment

200

color

white

solubility

0.1 M NaOH: 4 mg/mL, H₂O: 5.6 mg/mL, organic solvents: insoluble

SMILES string

NC(CCCP(O)(O)=O)C(O)=O

InChI

1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)

InChI key

VOROEQBFPPIACJ-UHFFFAOYSA-N

Gene Information

rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)

Description

Application

DL-2-Amino-5-phosphonopentanoic acid has been used:

in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
used in growth medium for inhibition of electrical activity in the neuronal network
used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)

Biochem/physiol Actions

Anticonvulsant; potent and selective NMDA receptor antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Hygroscopic

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This Item	A8054	217700	A4910
Sigma-Aldrich A5282 DL-2-Amino-5-phosphonopentanoic acid	Sigma-Aldrich A8054 D(−)-2-Amino-5-phosphonopentanoic acid	Sigma-Aldrich 217700 DL-2-Aminocaprylic acid	Sigma-Aldrich A4910 DL-2-Amino-3-phosphonopropionic acid
description solid	description NMDA receptor antagonist	description 99%	description -
form solid	form powder	form solid	form powder
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 200
solubility 0.1 M NaOH: 4 mg/mL, H₂O: 5.6 mg/mL, organic solvents: insoluble	solubility -	solubility -	solubility -
Gene Information rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)	Gene Information mouse ... Grin2a(14811) rat ... Grik1(29559), Grin2a(24409), Grin2b(24410), Grin2c(24411), Grin2d(24412)	Gene Information -	Gene Information human ... GRM1(2911), GRM2(2912), GRM3(2913), GRM4(2914), GRM5(2915), GRM6(2916), GRM7(2917), GRM8(2918)
color white	color white	color -	color -

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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