PHR1758

Thiourea

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Thiourea, Sulfourea, Thiocarbamide
• Linear Formula: NH₂CSNH₂
• CAS Number: 62-56-6
• Molecular Weight: 76.12
• Beilstein: 605327
• EC Number: 200-543-5
• MDL number: MFCD00008067
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823597
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• API family: propylthiouracil
• CofA: current certificate can be downloaded
• packaging: pkg of 200 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 170-176 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: NC(N)=S
• InChI: 1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
• InChI key: UMGDCJDMYOKAJW-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiourea is a chaotropic agent or strong denaturant. It has been used to solubilize membrane and organelle specific proteins for analysis by two-dimensional gel electrophoresis. Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and UV-induced crosslinking of collagen. As a chelator of cuprous copper, thiourea inhibits this intermediate in oxidative reactions of cupric ion. This process afforded protection of bovine albumin from copper-mediated oxidative reactions.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8226 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS08,GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302,H351,H361fd,H411
• Precautionary Statements: P202 - P264 - P270 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3