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D7402

Supelco

Drofenine hydrochloride

analytical standard

Synonym(s):

Hexahydroadiphenine

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About This Item

Empirical Formula (Hill Notation):
C20H31NO2 · HCl
CAS Number:
548-66-3
Molecular Weight:
353.93
EC Number:
208-954-1
MDL number:
MFCD00034983
UNSPSC Code:
41116107
PubChem Substance ID:
329798849

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

Cl.CCN(CC)CCOC(=O)C(C1CCCCC1)c2ccccc2

InChI

1S/C20H31NO2.ClH/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5,7-8,11-12,18-19H,3-4,6,9-10,13-16H2,1-2H3;1H

InChI key

WIELVDXKOYPANK-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Simultaneous determination of hydrochloride salts of adiphenine, diphenhydramine, ethyldiphenacetate, drofenine and promazine by ion-pair HPLC.
G Facchini et al.
Bollettino chimico farmaceutico, 122(8), 405-411 (1983-08-01)
E Bodur et al.
Archives of biochemistry and biophysics, 386(1), 25-29 (2001-05-22)
Benactyzine and drofenine are widely used anticholinergic drugs. Benactyzine is used to treat organophosphate poisoning and drofenine acts on smooth muscle to stop muscle spasms. Both of these drugs are esters. After they enter the bloodstream, they will interact with
E L Kunysz et al.
British journal of pharmacology, 93(3), 491-500 (1988-03-01)
1. Muscarinic receptor antagonists were examined in direct binding studies on guinea-pig cardiac and cortical muscarinic receptors. Pirenzepine, dicyclomine and hexahydroadiphenine were shown to be selective ligands for the putative M1-muscarinic receptor. 2. Functional affinity estimates of the muscarinic ligands

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