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Supelco

Clorsulon

VETRANAL®, analytical standard

Synonym(s):

4-Amino-6-(trichlorovinyl)-1,3-benzenedisulfonamide

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About This Item

Empirical Formula (Hill Notation):
C8H8Cl3N3O4S2
CAS Number:
60200-06-8
Molecular Weight:
380.66
EC Number:
262-100-2
MDL number:
MFCD00072006
UNSPSC Code:
41116107
PubChem Substance ID:
329754714
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Nc1cc(\C(Cl)=C(\Cl)Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O

InChI

1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)

InChI key

QOVTVIYTBRHADL-UHFFFAOYSA-N

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General description

Clorsulon, is a benzene sulphonamide and a flukicide, which is found to be effective against the adult and immature form of liver fluke, Fasciola hepatica in cattle.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG8206
BCBV4517
SZBE090XV
SZBB102XV
SZE9140X

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S F Sundlof et al.
Journal of veterinary pharmacology and therapeutics, 15(3), 282-291 (1992-09-01)
Clorsulon was measured in plasma and urine of sheep and goats after administration of a single intravenous (i.v.) and after a single oral dose of 7 mg/kg. A three-compartment model with elimination occurring from the central compartment was determined to
Y Vera Montenegro et al.
Parasitology research, 91(1), 1-4 (2003-07-05)
The efficacy of 5-chloro-2-methylthio-6-(1-napthyloxy)-1H-benzimidazole was evaluated with three commercial fasciolicides in terms of the percentage of egg reduction in cattle. Fifty Swiss cows were selected for inclusion in the trial based on finding eggs of Fasciola hepatica in their feces.
Induction of reversible urothelial cell hyperplasia in rats by clorsulon, a flukicide with weak carbonic anhydrase inhibitory activity
Lankas.RG and Peter.PC
Food And Chemical Toxicology, 30, 297-306 (1992)
M Meaney et al.
Parasitology research, 92(3), 232-241 (2004-01-10)
Using transmission electron microscopy (TEM), both the tegument and gut of Fasciola hepatica were examined in an effort to identify and characterise the ultrastructural changes induced following treatment with the flukicidal drug clorsulon. Male Sprague-Dawley rats infected with F. hepatica
M Meaney et al.
Parasitology research, 95(3), 201-212 (2005-01-13)
Three experiments have been carried out in vitro to determine the effect of oral and trans-tegumental uptake of clorsulon on the fine structure of the tegument and gut of Fasciola hepatica. Changes were assessed by transmission electron microscopy. In the
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