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292664

Sigma-Aldrich

N-tert-Butyl-α-(2-sulfophenyl)nitrone sodium salt

95%

Synonym(s):

2-SPBN sodium salt, 2-Sulfonatophenyl tert-butyl nitrone sodium salt

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About This Item

Linear Formula:
NaO3SC6H4CH=N(O)C(CH3)3
CAS Number:
73475-11-3
Molecular Weight:
279.29
MDL number:
MFCD00012017
UNSPSC Code:
12171500
PubChem Substance ID:
24857605
NACRES:
NA.47

Assay

95%

form

powder or crystals

mp

246 °C (dec.) (lit.)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].CC(C)(C)[N+](\[O-])=C\c1ccccc1S([O-])(=O)=O

InChI

1S/C11H15NO4S.Na/c1-11(2,3)12(13)8-9-6-4-5-7-10(9)17(14,15)16;/h4-8H,1-3H3,(H,14,15,16);/q;+1/p-1/b12-8-;

InChI key

LAIQBHGUFDAJKL-JCTPKUEWSA-M

Application

Water-soluble, negatively-charged spin trap used to monitor aqueous phase of SDS micelles.[1]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
10807DJ
13502HU
06816TF
21323LD
15211CZ

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Catherine E Hobbs et al.
Pediatrics international : official journal of the Japan Pediatric Society, 50(4), 481-488 (2008-10-22)
The production of oxygen free radicals after perinatal hypoxia-ischemia is thought to play a critical role in the pathogenesis of the brain injury. Administration of anti-oxidants may thus be neuroprotective. The aim of the present study was to investigate the
Maria Molnar et al.
Upsala journal of medical sciences, 115(3), 163-168 (2010-07-20)
Hyperglycemia exacerbates focal ischemic brain damage supposedly through various mechanisms. One such mechanism is oxidative stress involving reactive oxygen and nitrogen species (RONS) production. Nitrones attenuate oxidative stress in various models of brain injury. Sodium 2-sulfophenyl-N-tert-butyl nitrone (S-PBN) can be
Catherine E Hobbs et al.
Brain pathology (Zurich, Switzerland), 18(3), 443-454 (2008-03-29)
Perinatal hypoxia-ischemia can cause long-term neurological and behavioral disability. Recent multicenter clinical trials suggest that moderate hypothermia, within 6 h of birth, offers significant yet incomplete protection. We investigated the effect of combined treatment with the antioxidant N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN) and
N Klöcker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(3), 1038-1046 (1998-02-14)
Brain-derived neurotrophic factor (BDNF) partially promotes the survival of axotomized retinal ganglion cells (RGCs). In analogy with in vitro experiments (; ), we tested whether neuroprotection by BDNF is limited by adverse effects as a consequence of excessive free radical
Niklas Marklund et al.
Journal of neurotrauma, 19(10), 1139-1153 (2002-11-13)
Changes in regional cerebral blood flow (rCBF) and glucose metabolism are commonly associated with traumatic brain injury (TBI). Reactive oxygen species (ROS) have been implicated as key contributors to the secondary injury process after TBI. Here, pretreatment with the nitrone
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