ABS442

Anti-LZTR2 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): Leucine zipper-like transcription regulator 2, SEC16B, RGPR, RGPR-p117, KIAA1928, LZTR2, SEC16S, Regucalcin gene promoter region-related protein p117, Protein transport protein Sec16B, SEC16 homolog B
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: mouse
• species reactivity (predicted by homology): human (immunogen homology)
• technique(s): immunohistochemistry: suitable; western blot: suitable
• UniProt accession no.: Q96JE7
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... SEC16B(89866)

Description

General description

Leucine zipper-like transcription regulator 2 (LZTR2), also known as RGPR-p117, is a member of the SEC16 family and BTB-kelch superfamily. LZTR2 is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization. Initially, it was described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is localized in the cytoplasm but is thought to translocate to the nucleus following a hormonal stimulation and mediated by protein kinase C signaling. Recent studies has suggested that there is a strong correlation between LZTR2 and obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations. This evidence implies that LZTR2 may play an important role in metabolism and obesity risk.

Immunogen

KLH-conjugated linear peptide corresponding to human LZTR2.

Application

Anti-LZTR2 Antibody is a highly specific rabbit polyclonal antibody, that targets Leucine zipper-like transcription regulator 2 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected LZTR2 in mouse kidney tissue.

Research Category
Signaling

Research Sub Category
Metabolic Hormones & Receptors

Quality

Evaluated by Western Blotting in mouse kidney tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected LZTR2 in 15 µg of mouse kidney tissue lysate.

Target description

~92 kDa and ~140 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 3 isoforms at ~59 kDa, ~71 kDa, and ~117 kDa

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse kidney tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable