Leucine-rich glioma inactivated gene 1 (LGI1), also known as Epitempin-1 (EPT), is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) regulating voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. LGI1 may play a role in the control of neuroblastoma cell survival and may play a role in other cancers. It is expressed in neural tissue, especially brain. Mutations in LGI1 have been associated with nearly half of autodominant lateral temporal epilepsy (ADTLE).
Specificity
This antibody recognizes the N-terminus of LGI1.
Immunogen
KLH-conjugated linear peptide corresponding to the N-terminus of human LGI1.
Application
Detect LGI1 using this rabbit polyclonal antibody, Anti-LGI1 Antibody validated for use in western blotting.
Quality
Evaluated by Western Blotting/Peptide Inhibition Assay in mouse brain tissue lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected LGI1 in 15 µg of mouse brain tissue lysate.
Target description
~56 kDa observed. Uniprot describes 3 isoforms at ~33 kDa, ~58 kDa, and ~64 kDa Uncharacterized bands may appear in some lysates.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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