γ-Secretase Inhibitor IX, InSolution, ≥95%, 25 mM, g-secretase Inhibitor IX
Assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze desiccated (hygroscopic) protect from light
color
clear colorless
storage temp.
2-8°C
General description
A cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC50 = 115 nM; Aβ42 IC50 = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP695. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.
Biochem/physiol Actions
Primary Target Aβtotal
Target IC50: 115 nM, 200 nM against Aβtotal, Aβ42, respectively
Warning
Toxicity: Irritant (B)
Physical form
A 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
Reconstitution
Following initial use, aliquot and freeze (-20°C).
Other Notes
Oddo, S., et al. 2004. Neuron43, 321. Dovey, H.F., et al. 2001. J. Neurochem.76, 173. Vandermeeren, M., et al. 2001. Neurosci. Lett.315, 145.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
188.6 °F - closed cup - (refers to pure substance)
Flash Point(C)
87 °C - closed cup - (refers to pure substance)
Certificates of Analysis (COA)
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