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D8765

Sigma-Aldrich

Diethylcarbamazine citrate salt

≥98%

Synonym(s):

N,N-Diethyl-4-methyl-1-piperazinecarboxamide citrate salt

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About This Item

Linear Formula:
C10H21N3O · C6H8O7
CAS Number:
1642-54-2
Molecular Weight:
391.42
Beilstein:
3836352
EC Number:
216-696-6
MDL number:
MFCD00039124
UNSPSC Code:
12352100
PubChem Substance ID:
57654136

Assay

≥98%

form

powder

antibiotic activity spectrum

parasites

Mode of action

enzyme | inhibits

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)C(=O)N1CCN(C)CC1

InChI

1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

PGNKBEARDDELNB-UHFFFAOYSA-N

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H302,H330

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBV3157
SLBL0026V
SLBF1846V
079H1191
050K1524

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Koneni V Sashidhara et al.
Bioorganic & medicinal chemistry letters, 22(4), 1527-1532 (2012-01-31)
A series of 3,6-epoxy [1,5]dioxocines were synthesized and evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro. Out of these, six compounds (4a-f) possessed improved in vitro anti-filarial activity and
Ana Wládia Lima et al.
Revista da Sociedade Brasileira de Medicina Tropical, 45(6), 745-750 (2013-01-09)
The Global Programme to Eliminate Lymphatic Filariasis was launched with the goal of eliminating this disease via the annual mass drug administration (MDA) of a single dose of antifilarial drugs. Adverse drug reactions following MDA are a major factor of
Cathy Steel et al.
PLoS neglected tropical diseases, 6(12), e1940-e1940 (2012-12-14)
Antibody (Ab) to the Wuchereria bancrofti (Wb) infective larval (L3) antigen Wb123, using a Luciferase Immunoprecipitation System (LIPS) assay, has been shown to be a species-specific, early marker of infection developed for potential use as a surveillance tool following transmission
B K Singh et al.
European journal of medicinal chemistry, 43(12), 2717-2723 (2008-03-15)
A series of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines (8-21) were synthesized in good yields by alkylation of 5-methyl-6-phenyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid ethyl esters (2-7) with different alkyl or aralkyl halides in the presence of a combination of anhydrous K(2)CO(3) and catalytic amount of tetrabutyl ammonium bromide.
Rabindra Nath Roy et al.
Journal of health, population, and nutrition, 31(2), 171-177 (2013-08-13)
India adopted WHO's strategy of repeated rounds of mass drug administration (MDA) with diethylcarbamazine to eliminate lymphatic filariasis. The present study attempted to assess the coverage and awareness of and compliance with MDA for elimination of lymphatic filariasis in Burdwan
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