549967
2,4,6-Tri-tert-butylpyrimidine
97%
Synonym(s):
2,4,6-Tris(1,1-dimethylethyl)pyrimidine
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About This Item
Empirical Formula (Hill Notation):
C16H28N2
CAS Number:
Molecular Weight:
248.41
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
97%
mp
77-80 °C (lit.)
SMILES string
CC(C)(C)c1cc(nc(n1)C(C)(C)C)C(C)(C)C
InChI
1S/C16H28N2/c1-14(2,3)11-10-12(15(4,5)6)18-13(17-11)16(7,8)9/h10H,1-9H3
InChI key
VYWSYEDVFVGRGG-UHFFFAOYSA-N
Related Categories
General description
2,4,6-Tri-tert-butylpyrimidine (TTBP) is a non-hygroscopic sterically hindered base. It can be prepared by the reaction between tert-butyl methyl ketone and tert-butyronitrile.3 TTBP is a suitable alternative to 2,6-di-tert-butylated pyridines in glycosylation reactions.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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2, 4, 6-Tri-tert-butylpyrimidine (TTBP): A cost effective, readily available alternative to the hindered base 2, 6-di-tert-butylpyridine and its 4-substituted derivatives in glycosylation and other reactions.
Crich D, et al.
Synthesis, 2001(02), 0323-0326 (2001)
On the mechanism of the reaction between ketones and trifluoromethanesulfonic anhydride. An improved and convenient method for the preparation of pyrimidines and condensed pyrimidines.
Garcia Martinez A, et al.
The Journal of Organic Chemistry, 57(5), 1627-1630 (1992)
1-Benzenesulfinyl piperidine/trifluoromethanesulfonic anhydride: a potent combination of shelf-stable reagents for the low-temperature conversion of thioglycosides to glycosyl triflates and for the formation of diverse glycosidic linkages.
Crich D and Smith M.
Journal of the American Chemical Society, 123(37), 9015-9020 (2001)
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