Sodium hydrogencarbonate-13C is isotopically enriched compound of sodium bicarbonate.
Application
Sodium bicarbonate-13C can be used:
As a probe for NMR− and MRI− based pH imaging.[1][2][3]
To predict the reaction mechanism in selective hydrogenation of bicarbonate to formate, catalyzed by a ruthenium(III) complex.[4]
For 13C labeling of amino acid sample for compound-specific stable isotope analysis (CSIA).[5]
Sodium bicarbonate-13C is used to study the lactate metabolism by using hyperpolarized 13C pH imaging and multiparametric MRI.This reagent can be used as probe in nuclear magnetic resonance spectroscopy studies, which enabled large signal gains for low-toxicity hyperpolarized 13C pH imaging in a phantom and in vivo in a murine model of prostate cancer.
Packaging
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There is an unmet clinical need for new and robust imaging biomarkers to distinguish indolent from aggressive prostate cancer. Hallmarks of aggressive tumors such as a decrease in extracellular pH (pHe) can potentially be used to identify aggressive phenotypes. In
Magnetic resonance imaging of pH in vivo using hyperpolarized 13 C-labelled bicarbonate.
Gallagher FA, et al.
Nature, 453(7197), 940-940 (2008)
Quantified pH imaging with hyperpolarized 13 C-bicarbonate
Scholz DJ, et al.
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 73(6), 2274-2282 (2015)
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