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  • TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells.

TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells.

Scientific reports (2020-07-11)
Ján Remšík, Markéta Pícková, Ondřej Vacek, Radek Fedr, Lucia Binó, Aleš Hampl, Karel Souček
ZUSAMMENFASSUNG

The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-β family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-β disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.

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JC-1, solid
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Magnesium-methylcarbonat -Lösung, 2.0 M in DMF
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SIS3, ≥98% (HPLC), powder
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MISSION® esiRNA, targeting mouse Smad2