1417001

Methoxsalen

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): Xanthotoxin, 8-MOP, 8-Methoxypsoralen, 9-Methoxy-furo[3,2-g][1]benzopyran-7-on, Ammoidin, Methoxsalen
• Empirische Formel (Hill-System): C₁₂H₈O₄
• CAS-Nummer: 298-81-7
• Molekulargewicht: 216.19
• Beilstein: 196453
• MDL-Nummer: MFCD00005009
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329750415
• NACRES: NA.24

Eigenschaften

• Qualität: pharmaceutical primary standard
• API-Familie: methoxsalen
• Hersteller/Markenname: USP
• mp (Schmelzpunkt): 148-150 °C (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• SMILES String: COc1c2OC(=O)C=Cc2cc3ccoc13
• InChI: 1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
• InChIKey: QXKHYNVANLEOEG-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem./physiol. Wirkung

8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca²⁺].

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302,H317,H341,H351
• P-Sätze: P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2 - Muta. 2 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable