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Merck

V4765

Valnoctamide

≥98% (NMR)

Synonym(e):

2-ethyl-3-methyl-pentanamide, Axiquel, Nirvanil

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Über diesen Artikel

Empirische Formel (Hill-System):
C8H17NO
CAS-Nummer:
4171-13-5
Molekulargewicht:
143.23
NACRES:
NA.77
PubChem Substance ID:
329829054
UNSPSC Code:
12352200
MDL number:
MFCD00868184
Assay:
≥98% (NMR)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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Unterstützung erhalten

Quality Level

100

assay

≥98% (NMR)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

SMILES string

CCC(C)C(CC)C(N)=O

InChI

1S/C8H17NO/c1-4-6(3)7(5-2)8(9)10/h6-7H,4-5H2,1-3H3,(H2,9,10)

InChI key

QRCJOCOSPZMDJY-UHFFFAOYSA-N

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Dieser Artikel
V3640SML1503SML1624
Valnoctamide ≥98% (NMR)

Sigma-Aldrich

V4765

Valnoctamide

Valpromide ≥97% (NMR)

Sigma-Aldrich

V3640

Valpromide

Apcin ≥98% (HPLC)

Sigma-Aldrich

SML1503

Apcin

JNJ-63533054 ≥98% (HPLC)

Sigma-Aldrich

SML1624

JNJ-63533054

form

powder

form

powder

form

powder

form

powder

assay

≥98% (NMR)

assay

≥97% (NMR)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: >10 mg/mL

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

Application

Valnoctamide has been used:
  • as a mood stabilizer to study its anti-cytomegalovirus (anti-CMV) effects in newborn mice brain
  • as a hypnotic sedative to study its cytotoxic effects on oligodendrocyte precursor cells (OPCs) and human oligodendroglioma cell line (HOG)
  • as a mood stabilizer to study its effects on inhibition of human cytomegalovirus

Biochem/physiol Actions

Valproic acid (VPA) and derivatives such as valpromide and valnoctamide are anti-convulsant, mood stabilizing drugs, believed to function as indirect GABA agonists by inhibiting the transamination of GABA.
Valnoctamide exhibits anti-cytomegalovirus (anti-CMV) properties. It has therapeutic effects against status epilepticus (SE) and neuropathic pain. Valnoctamide also shows therapeutic effects against bipolar disorders.

Features and Benefits

This compound is featured on the Glutamate/GABA Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000194662
0000194662
0000072974
0000058056
0000058057

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

M Bialer
Journal of controlled release : official journal of the Controlled Release Society, 62(1-2), 187-192 (1999-10-16)
Valproic acid (VPA) is one of the major antiepileptic drugs. However, its anticonvulsant potency is less than the other three major antiepileptic drugs. Furthermore, VPA causes two rare but severe side effects: teratogenicity and hepatotoxicity. We utilized pharmacokinetic considerations in
Mood stabilizers inhibit cytomegalovirus infection
Ornaghi S, et al.
Virology, 499(29), 121-135 (2016)
Amidic derivatives of valproic acid as antiviral in HSV-1-infected oligodendrocytes.
Praena B, et al.
Antiviral Research, 54(29), 99-102 (2019)
S Blotnik et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(5), 560-564 (1996-05-01)
Valpromide (VPD) and valnoctamide (VCD) are amide derivatives of valproic acid (VPA), one of the major antiepileptic drugs (AEDs). In rodent models, both VPD and VCD are more potent as anticonvulsants than VPA. However, in humans, VPD served as a
F Pisani et al.
British journal of clinical pharmacology, 34(1), 85-87 (1992-07-01)
The effect of the valpromide isomer valnoctamide (VCD, 200 mg three times daily for 8 days), an over-the-counter tranquillizer, on the elimination kinetics of a single oral dose of carbamazepine-10, 11-epoxide (CBZ-E, 100 mg) was investigated in healthy subjects. During
Alle zugehörigen Dokumente anzeigen

Artikel

Glutamate/GABA Synthesis & Metabolism

Glutamine's role in neurotransmitter synthesis and transport highlights its importance in neuronal function and glutamate production.

Global Trade Item Number

SKUGTIN
V4765-5MG04061832561479
V4765-25MG04061832561462

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