V4758

Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse

clone 26503, purified immunoglobulin, lyophilized powder

• Synonym(e): Anti-VEGF
• UNSPSC Code: 51111800
• NACRES: NA.41
• MDL number: MFCD00282511
• Conjugate: unconjugated
• Clone: 26503, monoclonal
• Application: ELISA (c), Neutral, WB
• Citations: 14

Eigenschaften

• Quality Segment: 200
• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 26503, monoclonal
• form: lyophilized powder
• species reactivity: primate, human
• technique(s): capture ELISA: 2-8 μg/mL, neutralization: suitable, western blot: 1 μg/mL
• isotype: IgG2b
• UniProt accession no.: P15692
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... VEGFA(7422), VEGFB(7423), VEGFC(7424)

Beschreibung

General description

The antibody will neutralize the biological activity of recombinant human VEGF₁₆₅. It also recognizes VEGF₁₂₁.

Immunogen

purified recombinant Sf21-derived human VEGF (165 aa isoform).

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse was used to block the interaction between VEGF and kinase domain receptor in Calf Pulmonary Aortic Endothelial (CPAE) cells.

Biochem/physiol Actions

The vascular endothelial growth factor family consists of five members, VEGF-A to VEGF-E. They play important roles in important role in embryonic vasculogenesis, angiogenesis and homeostasis. The interaction between VEGFs and their respective receptors results in the activation of MAPK, PI3K, PKC, FAK and Src kinase pathways.

Physical form

Lyophilized from 0.2 um-filtered solution in PBS, pH 7.4 with 5% Trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)