V2514

Anti-VGLUT2 (HY-19) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(e): Anti-DNPI, Anti-VGLUT2
• MDL-Nummer: MFCD05865393
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 65 kDa
• Speziesreaktivität: rat
• Methode(n): western blot: 1:2,000 using synaptic vesicle (SV) fraction of rat brain
• UniProt-Hinterlegungsnummer: Q9JI12
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SLC17A6(57084) ; mouse ... Slc17a6(140919) ; rat ... Slc17a6(84487)

Beschreibung

Allgemeine Beschreibung

Vesicular glutamate transporter 2 (vGluT2), also known as solute carrier family 17 member 6 (SLC17A6), is encoded by the gene mapped to human chromosome 11p14.3. The encoded protein belongs to the SLC17 family of transporters. vGluT2 is an integral membrane protein with 12 predicted transmembrane domains. It is localized on synaptic vesicles and is expressed mainly in neurons and endocrine terminals.

Immunogen

synthetic peptide located near the C-terminus of rat VGLUT2 (amino acids 520-538). The sequence is identical in mouse and human VGLUT2 and has no homology to VGLUT1.

Anwendung

Anti-VGLUT2 (HY-19) antibody produced in rabbit has been used in:

• western blot
• immunolabelling.
• immunohistochemistry.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem./physiol. Wirkung

Vesicular glutamate transporters (vGluT) play a vital role in the transport of glutamate into secretory vesicles. They are also used as a specific markers to recognize glutamatergic neurons. vGluT2 is considered to be a potent target for reducing glutamatergic neurotransmission. Thus, vGluT2 could be useful for the treatment of neurodegenerative diseases in which chronic excessive glutamate signaling has been involved. It is also used for treating epilepsy and pain.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)