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V108

Sigma-Aldrich

(±)-Norverapamil hydrochloride

≥98% (HPLC)

Synonym(e):

N-Nor-(±)-verapamil hydrochloride

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About This Item

Empirische Formel (Hill-System):
C26H36N2O4 · HCl
CAS-Nummer:
67812-42-4
Molekulargewicht:
477.04
MDL-Nummer:
MFCD00078605
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24900707
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to beige

Löslichkeit

H2O: 15 mg/mL, clear

SMILES String

CC(C)C(CCCNCCC1=CC=C(OC)C(OC)=C1)(C#N)C2=CC(OC)=C(OC)C=C2.Cl

InChI

1S/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H

InChIKey

OEAFTRIDBHSJDC-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Norverapamil is an N-demethylated metabolite of verapamil. It has significantly less calcium channel blocking ability and exhibit therapeutic activity.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Yong-Ji Piao et al.
Archives of pharmacal research, 31(4), 518-522 (2008-05-02)
The aim of this study was to investigate the effects of hesperidin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats. The pharmacokinetic parameters of verapamil and norverapamil in rats were measured after the oral administration of
Stereoselective determination of verapamil and norverapamil by capillary electrophoresis
Dethy J M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 654(1), 121-127 (1994)
Simultaneous determination of verapamil and norverapamil in biological samples by high-performance liquid chromatography using ultraviolet detection
Garcia M A, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 693(2), 377-382 (1997)
M A Garcia et al.
Journal of chromatography. B, Biomedical sciences and applications, 693(2), 377-382 (1997-06-06)
In this paper we develop an high-performance liquid chromatographic method with ultraviolet detection for the determination of verapamil and its primary metabolite norverapamil in biological samples. Both compounds, as well as the internal standard, imipramine, were extracted from alkalinised blood
Young Sun Lee et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(8), 766-774 (2012-02-04)
In this study, the pharmacokinetics of verapamil and its active metabolite norverapamil were evaluated following intravenous and oral administration of 10 mg/kg verapamil to rats with hyperlipidaemia (HL) induced by poloxamer 407 (HL rats). The total area under the plasma
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