T9177

Tyrphostin AG 126

≥90%

• Synonym(e): (3-Hydroxy-4-nitrobenzylidene)malononitrile
• Empirische Formel (Hill-System): C₁₀H₅N₃O₃
• CAS-Nummer: 118409-62-4
• Molekulargewicht: 215.17
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278763
• MDL number: MFCD00236448

Eigenschaften

• assay: ≥90%
• storage temp.: −20°C
• SMILES string: Oc1cc(ccc1[N+]([O-])=O)\C=C(\C#N)C#N
• Gene Information: human ... TNF(7124)

Beschreibung

Application

Tyrphostin AG 126 has been used in LOPAC screening assays to identify histone deacetylase (HDAC) inhibitors.

Biochem/physiol Actions

Tyrphostin AG 126 is a tyrosine kinase inhibitor that is known to block the production of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in macrophages. Furthermore, studies have reported that AG 126 can reduce zymosan-induced multiple organ failure in rats, block the postoperative ileus development in mice, and also decrease colitis development in rats.

Sicherheitshinweise

• Lagerklasse: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges