T7569

Anti-phospho-Tau (pSer²⁶²) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(e): Anti-DDPAC, Anti-FTDP-17, Anti-MAPTL, Anti-MSTD, Anti-MTBT1, Anti-MTBT2, Anti-PPND, Anti-PPP1R103, Anti-TAU
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD03455773
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 4

Eigenschaften

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• species reactivity: rat, mouse, human
• technique(s): western blot: 1:1,000
• UniProt accession no.: P10636
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer262)
• Gene Information: human ... MAPT(4137) ; mouse ... Mapt(17762) ; rat ... Mapt(29477)

Beschreibung

General description

Tau (τ), also known as MAPT (microtubule associated protein tau) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons.

Immunogen

chemically synthesized phosphopeptide derived from the region of human tau that contains serine²⁶².

Biochem/physiol Actions

Removal of Tau (τ) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). Tau helps in the assembly and maintenance of microtubule structure. Measurement of phosphorylated tau (P-tau) levels in cerebrospinal fluid (CSF) acts a potential marker for differentiation between AD and dementia with Lewy bodies (DLB).

Physical form

Supplied in 100 μL of Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)