T6700

TRAM-34

≥98% (HPLC), Ca2+-activated K+ channel inhibitor, solid

• Synonym(e): 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
• Empirische Formel (Hill-System): C₂₂H₁₇ClN₂
• CAS-Nummer: 289905-88-0
• Molekulargewicht: 344.84
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826852
• NACRES: NA.77
• MDL number: MFCD09842562
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Produktname: TRAM-34, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: 2 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
• InChI: 1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
• InChI key: KBFUQFVFYYBHBT-UHFFFAOYSA-N

Beschreibung

Application

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Biochem/physiol Actions

TRAM-34 is a potent inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel.

TRAM-34 exhibits 100-fold selectivity (K_d = 20 nM) for IK_Ca1 channels over other K⁺ channels (Charybdotoxin, K_d = 5 nM, Clotrimazole, K_d = 70 nM; Nitrendipine K_d = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H413
• pcodes: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves