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T6700

Sigma-Aldrich

TRAM-34

≥98% (HPLC), solid

Synonym(e):

1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

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About This Item

Empirische Formel (Hill-System):
C22H17ClN2
CAS-Nummer:
289905-88-0
Molekulargewicht:
344.84
MDL-Nummer:
MFCD09842562
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329826852
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Farbe

off-white

Löslichkeit

DMSO: 2 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4

InChI

1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H

InChIKey

KBFUQFVFYYBHBT-UHFFFAOYSA-N

Anwendung

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Biochem./physiol. Wirkung

TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.
TRAM-34 is a potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302,H413

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 4

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Zhihua Yu et al.
Frontiers in cellular neuroscience, 11, 319-319 (2017-10-28)
Ischemic stroke is a devastating neurological disease that can initiate a phenotype switch in astrocytes. Reactive astrogliosis is a significant pathological feature of ischemic stroke and is accompanied by changes in gene expression, hypertrophied processes and proliferation. The intermediate-conductance Ca
Friederike A Steudel et al.
Molecular oncology, 11(9), 1172-1188 (2017-05-31)
Oncogenic signalling via Ca
H Wulff et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(14), 8151-8156 (2000-07-08)
The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated K(+) channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and diarrhea and is effective in ameliorating the symptoms of rheumatoid arthritis. However, inhibition of cytochrome
Rahini Kakumanu et al.
Toxins, 11(4) (2019-04-04)
Russell's viper (Daboia russelii) venom causes a range of clinical effects in humans. Hypotension is an uncommon but severe complication of Russell's viper envenoming. The mechanism(s) responsible for this effect are unclear. In this study, we examined the cardiovascular effects
Hanna Bueno-Levy et al.
Frontiers in pharmacology, 10, 1566-1566 (2020-02-06)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, stressed-provoked ventricular arrhythmia. CPVT is treated by β-adrenergic receptor blockers, Na+ channel inhibitors, sympathetic denervation, or by implanting a defibrillator. We showed recently that blockers of SK4 Ca2+-activated K+ channels depolarize the
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