T6060

Thioperamide maleate salt

• Synonym(e): MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
• Empirische Formel (Hill-System): C₁₅H₂₄N₄S · C₄H₄O₄
• CAS-Nummer: 148440-81-7
• Molekulargewicht: 408.52
• UNSPSC Code: 12352200
• MDL number: MFCD00083209

Eigenschaften

• solubility: H₂O: soluble 10 mg/mL, DMSO: soluble 12 mg/mL, ethanol: soluble 3 mg/mL
• SMILES string: OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3
• InChI: 1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: REZRBLGMJZZSID-BTJKTKAUSA-N

Beschreibung

Application

Thioperamide maleate has been used to study its effect on tau and TDP-43 aggregation³. It has also been used to study its effects on histamine induced contraction of trachealis in horses⁴.

Biochem/physiol Actions

Thioperamide is a H3 histamine receptor antagonist. Studies have reported that it can enhance MK-801-induced behavioral changes in rats⁵.

Preparation Note

Thioperamide maleate is soluble in water at 10 mg/ml, in ethanol at 3 mg/ml and in DMSO at 12 mg/ml.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves