SRP6590

Core Histones human

≥95% (SDS-PAGE)

• Synonym(e): HeLa Core Histones
• NACRES: NA.32
• UNSPSC Code: 12352200
• Form: liquid
• Assay: ≥95% (SDS-PAGE)
• Biological source: human

Eigenschaften

• biological source: human
• assay: ≥95% (SDS-PAGE)
• form: liquid
• packaging: pkg of 50 and 100 μg
• concentration: 1 mg/mL
• technique(s): cell based assay: suitable
• shipped in: dry ice
• storage temp.: −70°C

Beschreibung

General description

A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Further, histone H1 combines with these histones to form 30nm fibers. These fibers have six nucleosomes per turn in a solenoid arrangement. Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.

Physical form

50 mM sodium phosphate, pH 6.9, containing 10 mM sodium chloride and 1 mM β-mercaptoethanol.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H317,H319
• Sicherheitshinweise: P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable