SML4074

Trabectedin

≥98% (HPLC)

• Synonym(e): (1′R,6R,6aR,7R,13S,14S,16R)-6′,8,14-Trihydroxy-7′,9-dimethoxy-4,10,23-trimethyl-19-oxo-3′,4′,6,7,12,13,14,16-octahydrospiro(6,16-(epithiopropanooxymethano)-7,13-imino-6aH-1,3-dioxolo(7,8)isoquino(3,2-b)(3)benzazocine-20,1′(2′H)-isoquinolin)-5-yl acetate, 1′R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3′,4′,6,6a,7,13,14,16-octahydro-6′,8,14-trihydroxy-7′,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1′(2′H)-isoquinolin]-19-one, ET-743, Ecteinascidin 743
• Empirische Formel (Hill-System): C₃₉H₄₃N₃O₁₁S
• CAS-Nummer: 114899-77-3
• Molekulargewicht: 761.84
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: CC(C1=C2OCO1)=C(OC(C)=O)C3=C2[C@H](CO4)N([C@@H](O)[C@H]5N(C)[C@@H]6C7=C(C5)C=C(C)C(OC)=C7O)C6[C@H]3SC[C@@]8(C4=O)NCCC9=C8C=C(OC)C(O)=C9
• InChI: 1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/
• InChI key: PKVRCIRHQMSYJX-CXIMGACLSA-N

Beschreibung

Biochem/physiol Actions

Anti-proliferative; a potent anticancer agent.


Trabectedin is an alkylating drug that binds guanine residues in the minor groove of DNA, causing RNA polymerase II arrest, interfering with transcription and DNA repair pathways. It is anti-proliferative, a potent anticancer agent that has been approved to treat advanced soft tissue sarcoma and is being investigated for treatment of multiple other cancers.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Danger
• hcodes: H340,H361fd,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 1B - Repr. 2 - STOT RE 2 Inhalation
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable