SML3970

S1RA

≥98% (HPLC)

• Synonym(e): 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine, E 52862, E-52862, E52862, MR 309, MR-309, MR309
• Empirische Formel (Hill-System): C₂₀H₂₃N₃O₂
• CAS-Nummer: 878141-96-9
• Molekulargewicht: 337.42
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD25976945
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , White to light Brown
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: room temp

Beschreibung

Biochem/physiol Actions

Selective, high-affinity sigma-1 receptor antagonist with antinociceptive efficacy in vivo.



S1RA (E-52862) is a selective, high-affinity sigma-1 receptor antagonist (human/guinea pig σ1 Ki = 17/23.5 nM; σ2 Ki = 9.3 μM/rat, >1 μM/guinea pig). S1RA exerts dose-dependent antinociceptive effects in several neuropathic pain models in mice in vivo (16 - 64 mg/kg i.p.).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable