SML3942

DUB-IN-2

≥98% (HPLC)

• Synonym(e): 9-Ethoxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, DUB Inhibitor 2, DUBs Inhibitor 2, DUBs-IN-2, Deubiquitinase Inhibitor 2
• Empirische Formel (Hill-System): C₁₅H₉N₅O
• CAS-Nummer: 924296-19-5
• Molekulargewicht: 275.26
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor.

DUBs-IN-2 is a potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor (IC50 = 280 nM/USP8, >100 µM/USP7). DUBs-IN-2 inhibits the proliferation of gastric cancer (GC) cell NCI-N87 in cultures (IC50 = 480 nM post 3-day incubation) and NCI-N87-derived tumor growth in mice in vivo (2 mg/kg/d 5x per wk) by promoting HER-2 degradation.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3