SML3700

TPC2-A1-P

≥98% (HPLC), Two pore segment channel 2 (TCP2) agonist, powder

• Synonym(e): 5-(5-Bromo-2-(trifluoromethoxy)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid, TPC2 agonist H07
• Empirische Formel (Hill-System): C₂₀H₂₁BrF₃NO₃
• CAS-Nummer: 2804595-86-4
• Molekulargewicht: 460.28
• UNSPSC Code: 12352200
• NACRES: NA.21
• MDL number: MFCD32878271
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: TPC2-A1-P, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

Selective two pore segment channel 2 (TCP2) agonist that preferentially mimics the Na+ signals-inducing action of PI(3,5)P2.

TPC2-A1-P is a selective two pore segment channel 2 (TCP2) agonist that mimics the action of PI(3,5)P2 where it preferentially induces Na+ signals (EC50 = 0.6 µM). In contrast, TPC2-A1-N is a much weaker Ca2+ current inducer when compared to NAADP and TPC2-A1-N. TPC2-A1-P, but not the Ca2+ signals agonist TPC2-A1-N, activates TPC2-dependent lysosomal exocytosis (30 µM, murine macrophages), while TPC2-A1-N, but not TPC2-A1-P, causes TPC2-dependent alkalinization of lysosomal lumen Ca2+ stores (10 µM, TPC2-expressing HeLa cells).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable