SML3435

Momordin Ιc

≥98% (HPLC)

• Synonym(e): (3β)-17-Carboxy-28-norolean-12-en-3-yl 3-O-β-D-xylopyranosyl-β-D-glucopyranosiduronic acid, Mormordin Ic
• Empirische Formel (Hill-System): C₄₁H₆₄O₁₃
• CAS-Nummer: 96990-18-0
• Molekulargewicht: 764.94
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D 12 to 17° in methanol (c=0.5 g/100mL)
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: -10 to -25°C
• SMILES String: O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1C(=O)O)O)O[C@@H]7OC[C@H]([C@@H]([C@H]7O)O)O)O)O[C@@H]2C([C@H]3[C@@]([C@@H]4[C@]([C@@]5(CC[C@@]6([C@@H](CC(CC6)(C)C)C5=CC4)C(=O)O)C)(CC3)C)(CC2)C)(C)C
• InChI: 1S/C41H64O13/c1-36(2)14-16-41(35(49)50)17-15-39(6)20(21(41)18-36)8-9-24-38(5)12-11-25(37(3,4)23(38)10-13-40(24,39)7)52-34-29(46)30(28(45)31(54-34)32(47)48)53-33-27(44)26(43)22(42)19-51-33/h8,21-31,33-34,42-46H,9-19H2,1-7H3,(H,47,48)(H,49,50)/t21-,22+,23-,24+,25-,26-,27+,28-,29+,30-,31-,33-,34+,38-,39+,40+,41-/m0/s1
• InChIKey: HWYBGIDROCYPOE-WEAQAMGWSA-N

Beschreibung

Allgemeine Beschreibung

Momordin Ιc is a pentacyclic triterpenoid isolated from Kochia scoparia (L.) fruit and other medicinal plants.

Biochem./physiol. Wirkung

Momordin Ic is a potent inhibitor of SUMO-specific protease 1 (SENP1) that increases SUMOylated proteins in PC3 cells. It inhibits cell proliferation and induces cell death in prostate cancer PC3 xenograft mouse model. Momordin Ιc decreases serum glucose and ethanol levels after oral administration through acceleration of gastrointestinal transit.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable