SML3337

CBR-470-1, racemic

≥98% (HPLC)

• Synonym(e): (± )-3-((4-chlorophenyl)sulfonyl)-4-(isobutylamino)tetrahydrothiophene 1,1-dioxide, 3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel- (ACI)
• Empirische Formel (Hill-System): C₁₄H₂₀ClNO₄S₂
• CAS-Nummer: 2416095-06-0
• Molekulargewicht: 365.90
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD31735115
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2%, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

CBR-470-1 is an Inhibitor of the glycolytic enzyme PGK1 that induces Nrf2 activity. PGK1 inhibition results in acculumation of methylglyoxalyl (MGO), a toxic, reactive metabolite removed by other enzymes. The accumulated MGO then irreversibly reacts with Keap1 forming inactive Keap1 dimers, resulting in accumulation of Nrf2.

Inhibitor of the glycolytic enzyme PGK1 inducing Nrf2 activity

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable