SML3319

WM-3835

≥98% (HPLC)

• Synonym(e): N′-(4-Fluoro-5-methylbiphenylcarbonyl)-3-hydroxybenzenesulfonohydrazide, WM 3835, WM3835, [1,1’-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-[(3-hydroxyphenyl)sulfonyl]hydrazide
• Empirische Formel (Hill-System): C₂₀H₁₇FN₂O₄S
• CAS-Nummer: 2229025-70-9
• Molekulargewicht: 400.42
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD34179539
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: soluble
• storage temp.: −20°C
• SMILES string: OC1=CC(S(NNC(C2=CC(C3=CC=CC=C3)=CC(C)=C2F)=O)(=O)=O)=CC=C1
• InChI: 1S/C20H17FN2O4S/c1-13-10-15(14-6-3-2-4-7-14)11-18(19(13)21)20(25)22-23-28(26,27)17-9-5-8-16(24)12-17/h2-12,23-24H,1H3,(H,22,25)
• InChI key: KVJFJJXCBRSCDY-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Cell-permeable, potent, selective, Ac-CoA competitive and reversible inhibitor of HBO1, KAT6A, and TIP60 acetyltransferases

WM-3835is a cell-permeable hydroxybenzenesulfonohydrazide compound that acts as a potent, selective, Ac-CoA competitive and reversible inhibitor of HBO1, KAT6A, and TIP60 acetyltransferases (IC50 = 0.030, 0.017 and 0.312 µM, respectively). WM-3835 is non-cytotoxic, dose-dependently, and rapidly decreases H3K14Ac levels (IC50 = 0.341 µM) and inhibits AML cells growth (IC50 = 0.297 µM in Molm13). Induces apoptosis, downregulates HOXA and IL-6 expression and up-regulates ALB secretion and delays hepatocyte and hMPC senescence. WM-1385 potently inhibits POS-1 xenograft growth in SCID mice (10 mg/kg, i.p.).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable