SML3245

dCBP-1

≥98% (HPLC)

• Synonym(e): 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1-[1-[15-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-4-piperidinyl]-1,4,6,7-tetrahydro-N-methyl-5H-pyrazolo[4,3-c]pyridine-5-carboxamide
• Empirische Formel (Hill-System): C₅₁H₆₃F₂N₁₁O₁₀
• CAS-Nummer: 2484739-25-3
• Molekulargewicht: 1028.11
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C(N1CCC(CC1)N2N=C(C3=C2CCN(C3)C(NC)=O)N4C5=C(CCC4)C=C(C6=CN(N=C6)C)C(C(F)F)=C5)CCOCCOCCOCCOCCNC7=CC=C(C8=C7)C(N(C8=O)C9C(NC(CC9)=O)=O)=O
• InChI: 1S/C51H63F2N11O10/c1-54-51(70)61-17-11-41-40(31-61)47(62-14-3-4-32-26-37(33-29-56-59(2)30-33)38(46(52)53)28-43(32)62)58-64(41)35-9-15-60(16-10-35)45(66)12-18-71-20-22-73-24-25-74-23-21-72-19-13-55-34-5-6-36-39(27-34)50(69)63(49(36)68)42-7-8-44(65)57-48(42
• InChIKey: ILVRLRGBSSFKIE-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Highly potent and selective bifunctional PROTAC degrader of CREB-binding protein (CBP) and p300 (p300/CBP)

dCBP-1 is a highly potent and selective bifunctional PROTAC degrader of CREB-binding protein (CBP) and p300 (p300/CBP) that potently inhibits enhancer-mediated transcription. dCBP-1 induces complete loss of p300/CBP in multiple cellular models of multiple myeloma.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable