SML3152

MitoPQ

≥90% (HPLC), mitochondria-targeted redox cycler, powder

• Synonym(e): 1-Methyl-1′-[10′′-(triphenylphosphonio)decyl)dec-1"-yl]-4,4′-bipyridine-1,1′-diium triiodide, MPQ, Mito-PQ, MitoParaquat, Mitochondria-targeted paraquat, mtPQ
• Empirische Formel (Hill-System): C₃₉H₄₆N₂P·3I
• CAS-Nummer: 1821370-28-8
• Molekulargewicht: 954.48
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥90% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: MitoPQ, ≥90% (HPLC)
• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: powder
• storage condition: desiccated
• color: brown to brown-red
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]
• InChI: 1S/C39H46N2P.3HI/c1-40-30-25-35(26-31-40)36-27-32-41(33-28-36)29-17-6-4-2-3-5-7-18-34-42(37-19-11-8-12-20-37,38-21-13-9-14-22-38)39-23-15-10-16-24-39;;;/h8-16,19-28,30-33H,2-7,17-18,29,34H2,1H3;3*1H/q+3;;;/p-3
• InChI key: AOZZGHKENAZYTD-UHFFFAOYSA-K

Beschreibung

General description

MitoPQ (MitoParaquat) is a mitochondria-targeted redox cycler composed of the lipophilic triphenylphosphonium (TP) cation-conjugated paraquat that induces mitochondria superoxide production via redox cycling at the complex I flavin site. MitoPQ increases mitochondria superoxide production at a ~1000-fold higher efficacy than untargeted paraquat using either live cells (fold of change of MitoSox fluorescence = 1.4/1 μM & 3.2/5 μM MitoPQ vs 1.2/5 mM PQ; C2C12 myoblasts) or isolated mitochondria (fold of increase of H2O2 efflux = 4.6/1 μM MitoPQ vs 2.6/1 mM PQ; rat heart mitochondria). MitoPQ is a valuable tool for conducting cellular and in vivo investigations into the role of mitochondrial superoxide generation in redox biology. Additionally, it can be utilized as a catalyst or co-stressor to replicate metabolic and neurodegenerative disease traits in experimental models.[1]

Application

MitoPQ has been used to enhance mitochondrial reactive oxygen species (mitoROS) production in T-cell culture and investigate its influence over T-cell differentiation.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable