SML3019

TH1760

≥98% (HPLC)

• Synonym(e): 6-{[4-(1H-indole-5-carbonyl)piperazin-1-yl]sulfonyl}-2,3-dihydro-1,3-benzoxazol-2-one
• Empirische Formel (Hill-System): C₂₀H₁₈N₄O₅S
• CAS-Nummer: 2567914-01-4
• Molekulargewicht: 426.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=S(C1=CC(O2)=C(C=C1)NC2=O)(N3CCN(CC3)C(C4=CC5=C(C=C4)NC=C5)=O)=O

Beschreibung

Biochem/physiol Actions

TH1760 is a cell penetrant, potent and selective inhibitor of NUDT15 (NUDIX-type 15) that directly binds into the NUDT15 catalytic pocket. TH1760 sensitized cells to 6-thioguanine.

cell penetrant, potent and selective inhibitor of NUDT15 (NUDIX-type 15) that directly binds into the NUDT15 catalytic pocket

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable