SML2639

BDT001

≥98% (HPLC)

• Synonym(e): N-(5-Chloro-2-hydroxyphenyl)-3-(piperidin-1-ylsulfonyl) benzamide
• Empirische Formel (Hill-System): C₁₈H₁₉ClN₂O₄S
• CAS-Nummer: 823837-22-5
• Molekulargewicht: 394.87
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=CC=C(C=C1NC(C2=CC=CC(S(N3CCCCC3)(=O)=O)=C2)=O)Cl
• InChI key: GRZNJWNQXQKQQL-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

BDT001 is a selective negative allosteric modulator of Flt-3 receptor tyrosine kinase. It showed minimal binding to 25 diverse RTKs and 49 intracellular kinases. In primary cultures of adult DRG neurons, BDT001 reversed the potentiation of capsaicin-induced TRPV1 activation by FL, with a maximal effect at 1 μM. In a mouse study BDT001 alleviated nerve injury-induced peripheral neuropathic pain but had no effect on nociception in non-injured animals.

Negative allosteric modulator of Flt-3 receptor tyrosine kinase

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable