SML2386

Cycloguanil hydrochloride

≥95% (HPLC)

• Synonym(e): 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine hydrochloride
• Empirische Formel (Hill-System): C₁₁H₁₄ClN₅ · HCl
• CAS-Nummer: 152-53-4
• Molekulargewicht: 288.18
• UNSPSC Code: 12352200
• MDL number: MFCD00035308
• NACRES: NA.21
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: Clc1ccc(cc1)N2C(NC(=N)NC2=N)(C)C.Cl
• InChI: 1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H
• InChI key: MOUAPRKJJUXEIE-UHFFFAOYSA-N

Beschreibung

Application

Cycloguanil hydrochloride is suitable for use as a positive control in screening Plasmodium falciparum strains in microdilution radioisotope antiplasmodial bioassay. It may also be used as internal standard in high performance liquid chromatography for the quantification of urine and plasma samples.

Biochem/physiol Actions

Cycloguanil, a metabolite of proguanil, is a potent dihydrofolate reductase inhibitor.

Dihydrofolate reductase inhibitor, metabolite of proguanil

Cycloguanil is it a potential antimalarial drug. It is hydrophilic in nature. Cycloguanil acts as a substrate for the enzyme organic cation transporter 1 (OCT1).

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Lagerklasse: 4.1B - Flammable solid hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable