SML2231

Erasin

≥98% (HPLC)

• Synonym(e): (E)-N′-((6-(tert-butyl)-4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide, Erlotinib-resistance antagonizing STAT3 inhibitor
• Empirische Formel (Hill-System): C₂₀H₁₉N₃O₃
• CAS-Nummer: 2256056-21-8
• Molekulargewicht: 349.38
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C1C(/C=N/NC(C2=CC=CN=C2)=O)=COC3=CC=C(C(C)(C)C)C=C31

Beschreibung

Biochem./physiol. Wirkung

Erasin (Erlotinib-resistance antagonizing STAT3 inhibitor) is a selective inhibitor of STAT3 with selectivity over STAT5 and STAT1 in cell-based assays. It was shown to increase the apoptotic rate of HCC-827 cells with acquired resistance against Erlotinib in addition to increasing the apoptotic rate of cultured NSCLC cells in a STAT3-dependent manner.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable