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SML1571

S14161

≥98% (HPLC)

Synonym(e):

8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran, 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene, Pichromene

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Über diesen Artikel

Empirische Formel (Hill-System):
C17H14FNO4
CAS-Nummer:
Molekulargewicht:
315.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated, protect from light


Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to beige

storage temp.

−20°C

SMILES string

FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2

InChI

1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3

InChI key

BFZXDHIUPNWOMT-UHFFFAOYSA-N

Biochem/physiol Actions

S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.

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Dieser Artikel
SML2724SML1188SML0801
form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

desiccated, protect from light

storage condition

-

storage condition

-

storage condition

-

color

white to beige

color

white to beige

color

, white to very dark brown

color

white to beige


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Irrit. 2

Lagerklasse

11 - Combustible Solids

wgk

WGK 3



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