SML1554

S3QEL 2

superoxide production inhibitor, powder

• Synonym(e): 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• Empirische Formel (Hill-System): C₁₉H₂₅N₅
• CAS-Nummer: 890888-12-7
• Molekulargewicht: 323.44
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: powder

Eigenschaften

• Produktname: S3QEL 2,
• form: powder
• Quality Segment: 100
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear
• storage temp.: −20°C

Beschreibung

Biochem/physiol Actions

S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation.

S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation. Site IIIQo is the primary source of mitochondrial reactive oxygen species (ROS) and has been implicated in a broad range of ROS-mediated signaling and pathology. S3QEL 2 lowered HIF-1α induction, protected against ROS-induced, JNK-mediated cell stress in pancreatic beta-cells, and decreased the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.

S3QEL 2, a cell permeable substituted allopurinol, is also known as 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable