Direkt zum Inhalt
Merck

Fortfahren mit

SML1538

NMDI14

≥97% (HPLC), nonsense-mediated RNA decay inhibitor, powder

Synonym(e):

4,5-Dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-3-thiophenecarboxylic acid ethyl ester, Ethyl 2-{[(6,7–dimethyl–3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate

zur Ansicht der Organisations- und Vertragspreise.

Über diesen Artikel

Empirische Formel (Hill-System):
C21H25N3O4S
CAS-Nummer:
Molekulargewicht:
415.51
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
powder


Produktname

NMDI14, ≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 0.2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[s]1c(c(c(c1C)C)C(=O)OCC)NC(=O)CC2Nc3c(cc(c(c3)C)C)NC2=O

InChI key

QRLPSNLBUMVXBL-UHFFFAOYSA-N

Application

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:
  • to study its effects on differentiating cardiomyocytes[1]
  • to study its effects on zebrafish pdzk1 gene-knockout embryos[2]
  • to analyze its effects on the apoptosis of colorectal cancer cells[3]

Biochem/physiol Actions

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.
Potent nonsense-mediated RNA decay (NMD) inhibitor


Still not finding the right product?

Explore all of our products under NMDI14


Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Dokumente section.

Wenn Sie Hilfe benötigen, wenden Sie sich bitte an Kundensupport

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen



Questions

Reviews

No rating value

Active Filters