SML1529

Erdosteine

≥98% (HPLC), powder, mucolytic agent

• Synonym(e): ({2-Oxo-2-[(2-oxotetrahydro-3-thienyl)amino]ethyl}sulfanyl)acetic acid, 2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetic acid
• Empirische Formel (Hill-System): C₈H₁₁NO₄S₂
• CAS-Nummer: 84611-23-4
• Molekulargewicht: 249.31
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825946
• NACRES: NA.77
• MDL number: MFCD00867664
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Erdosteine, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S1CCC(C1=O)NC(=O)CSCC(=O)O
• InChI: 1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)
• InChI key: QGFORSXNKQLDNO-UHFFFAOYSA-N

Beschreibung

General description

Erdosteine is a derivative of thiol, and is used in the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis.It consists of two blocked sulfhydryl groups, which are released following first-pass metabolism.[1]

Application

Erdosteine has been used as a mucolytic to study its protective effects on interleukin-1β-stimulated inflammation in rat chondrocytes in osteoarthritis models.[2]

Biochem/physiol Actions

Erdosteine is a mucolytic drug with expectorant and antitussive effects.

Erdosteine is a mucolytic drug with expectorant and antitussive effects. Erdosteine is quickly metabolized in vivo to free thiols which act as free radical scavengers. Erdosteine has also been shown to have antioxidant activity through the activation of Nrf2-dependent antioxidant genes and inhibition of pro-inflammatory cytokines.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable