SML1450

Isobavachalkon

≥98% (HPCE)

• Synonym(e): Corylifolinin, Isobacachalkon
• Empirische Formel (Hill-System): C₂₀H₂₀O₄
• CAS-Nummer: 20784-50-3
• Molekulargewicht: 324.37
• MDL-Nummer: MFCD00902090
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825889
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPCE)
• Form: powder
• Lagerbedingungen: desiccated; protect from light
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: −20°C
• SMILES String: OC1=C(CC=C(C)C)C(O)=C(C(/C=C/C2=CC=C(O)C=C2)=O)C=C1
• InChI: 1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+
• InChIKey: DUWPGRAKHMEPCM-IZZDOVSWSA-N

Beschreibung

Biochem./physiol. Wirkung

Isobavachalcone is a chalcone isolated from multipurpose medical plant Psoralea corylifolia that inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cells. It appears that isobavachalcone modulates both MyD88-dependent and TRIF-dependent signaling of toll-like receptor 4 (TLR4). Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42. Isobavachalcone exhibits a wide spectrum of biological activities including antioxidative, antiplatelet, antimicrobial, anti-inflammatory, antitumor, and neuroprotective.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable