SML1450

Isobavachalkon

≥98% (HPCE), Akt inhibitor, powder

• Synonym(e): Corylifolinin, Isobacachalkon
• Empirische Formel (Hill-System): C₂₀H₂₀O₄
• CAS-Nummer: 20784-50-3
• Molekulargewicht: 324.37
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825889
• NACRES: NA.77
• MDL number: MFCD00902090
• Assay: ≥98% (HPCE)
• Form: powder
• Storage condition: desiccated, protect from light

Eigenschaften

• Produktname: Isobavachalkon, ≥98% (HPCE)
• Quality Segment: 100
• assay: ≥98% (HPCE)
• form: powder
• storage condition: desiccated, protect from light
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: OC1=C(CC=C(C)C)C(O)=C(C(/C=C/C2=CC=C(O)C=C2)=O)C=C1
• InChI: 1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+
• InChI key: DUWPGRAKHMEPCM-IZZDOVSWSA-N

Beschreibung

Biochem/physiol Actions

Isobavachalcone is a chalcone isolated from multipurpose medical plant Psoralea corylifolia that inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cells. It appears that isobavachalcone modulates both MyD88-dependent and TRIF-dependent signaling of toll-like receptor 4 (TLR4). Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42. Isobavachalcone exhibits a wide spectrum of biological activities including antioxidative, antiplatelet, antimicrobial, anti-inflammatory, antitumor, and neuroprotective.

Isobavachalcone is a chalcone isolated from multipurpose medical plant Psoralea corylifolia that inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cells.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable