SML1136

SW155246

≥98% (HPLC)

• Synonym(e): 4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
• Empirische Formel (Hill-System): C₁₆H₁₁ClN₂O₅S
• CAS-Nummer: 420092-79-1
• Molekulargewicht: 378.79
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825672
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to light brown
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=CC=C(NS(=O)(C2=CC=C(Cl)C([N+]([O-])=O)=C2)=O)C3=C1C=CC=C3
• InChI: 1S/C16H11ClN2O5S/c17-13-6-5-10(9-15(13)19(21)22)25(23,24)18-14-7-8-16(20)12-4-2-1-3-11(12)14/h1-9,18,20H
• InChI key: JDYDEJYIVZNWQU-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor that demethylates cytosines in vivo in a cell-based assay without affecting protein levels or generating reactive oxygen species. SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.

SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

light sensitive

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H319
• Sicherheitshinweise: P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2
• Lagerklasse: 13 - Non Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable