SML0494

VU0361737

≥98% (HPLC)

• Synonym(e): CID-44191096, ML128, N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
• Empirische Formel (Hill-System): C₁₃H₁₁ClN₂O₂
• CAS-Nummer: 1161205-04-4
• Molekulargewicht: 262.69
• MDL-Nummer: MFCD16618402
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825444
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: film
• Farbe: white
• Löslichkeit: DMSO: 15 mg/mL (clear solution)
• Lagertemp.: 2-8°C
• SMILES String: COc1cc(NC(=O)c2ccccn2)ccc1Cl
• InChI: 1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
• InChIKey: ARYUXFNGXHNNDM-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

VU0361737 is an mGluR4-specific positive allosteric modulator (PAM) with greater than 50 fold selectivity over other mGluR subtypes. The EC₅₀ values for human and rat mGlu4 are 240 and 110 nM, respectively, compared to greater than 10 mM for all other mGluRs.

Leistungsmerkmale und Vorteile

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H319
• P-Sätze: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable