SML0473

Noladin ether

≥98% (HPLC)

• Synonym(e): 2-Arachidonylglyceryl ether, 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yloxy]-1,3-propanediol; 2-AG ether, HU 310
• Empirische Formel (Hill-System): C₂₃H₄₀O₃
• CAS-Nummer: 222723-55-9
• Molekulargewicht: 364.56
• UNSPSC Code: 12352200
• EC Number: 200-578-6
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solution

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solution
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• concentration: 10 mg/mL in ethanol (1% w/v)
• color: colorless to light yellow
• shipped in: dry ice
• storage temp.: −70°C
• SMILES string: O(C(CO)CO)CCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
• InChI: 1S/C23H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26-23(21-24)22-25/h6-7,9-10,12-13,15-16,23-25H,2-5,8,11,14,17-22H2,1H3/b7-6-,10-9-,13-12-,16-15-
• InChI key: CUJUUWXZAQHCNC-DOFZRALJSA-N

Beschreibung

Biochem/physiol Actions

Noladin ether (2-Arachidonyl glycerol ether) is a CB1 agonist.

Noladin ether (2-Arachidonyl glycerol ether) is a stable analog of the endogenous cannabanoid 2-Arachidonylglycerol (2-AG) with selectivity for CB1 receptors. Noladin ether is a CB1 agonist. The Ki values for CB1 vs CB2 receptors are 21.2 nM and 3 mM, respectively. Noladin ether induces sedation and has modest antinociceptive activity in vivo, and reduces inter ocular pressure after administration in the eye.

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

Sicherheitshinweise

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Lagerklasse: 3 - Flammable liquids
• wgk: WGK 2
• flash_point_f: 57.2 °F - closed cup
• flash_point_c: 14.0 °C - closed cup