SML0230

GW-803430

≥98% (HPLC)

• Synonym(e): 6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one, GW-3430, GW-803430A
• Empirische Formel (Hill-System): C₂₅H₂₄ClN₃O₃S
• CAS-Nummer: 515141-51-2
• Molekulargewicht: 481.99
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥4 mg/mL at warmed to 60 °C
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: [s]1c2c(nc[n]([c]2=O)c4cc(c(cc4)OCCN5CCCC5)OC)cc1c3ccc(cc3)Cl
• InChI: 1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3
• InChI key: MWULMTACIBZPGN-UHFFFAOYSA-N

Beschreibung

Application

GW-803430 may be used in MCHR1-mediated cell signaling studies.

Biochem/physiol Actions

GW-803430 antagonizes central MCHR1 and produces anxiolytic, anti-depressant and anti-obesity effects in rats and mice.[1] It also controls the alcohol-seeking behavior in rats and is a promising treatment for alcohol use-related disorders.[2]

GW-803430 is a centraly active and selective melanin-concentrating hormone receptor (MCHR) 1 antagonist

Features and Benefits

This compound is featured on the Melanin-Concentrating Hormone Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable