SML0207

SB 328437

≥98% (HPLC)

• Synonym(e): L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester
• Empirische Formel (Hill-System): C₂₁H₁₈N₂O₅
• CAS-Nummer: 247580-43-4
• Molekulargewicht: 378.38
• NACRES: NA.77
• PubChem Substance ID: 329825229
• UNSPSC Code: 12352202
• MDL number: MFCD16618397
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥10 mg/mL
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23
• InChI: 1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
• InChI key: VMFGCGRAIBLAFY-IBGZPJMESA-N

Beschreibung

Application

SB 328437 may be used to study CCR3-mediated cell signaling in asthma models.

Biochem/physiol Actions

SB-328437 is a CCR3 Antagonist.

SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.

SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.

Features and Benefits

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable