SML0097

Nevirapin

≥98% (HPLC), HIV-1 reverse transcriptase inhibitor, powder

• Synonym(e): 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
• Empirische Formel (Hill-System): C₁₅H₁₄N₄O
• CAS-Nummer: 129618-40-2
• Molekulargewicht: 266.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825155
• NACRES: NA.77
• MDL number: MFCD00866928
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Nevirapin,
• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: powder
• color: white to tan
• solubility: DMSO: ≥22 mg/mL
• storage temp.: room temp
• SMILES string: CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
• InChI: 1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
• InChI key: NQDJXKOVJZTUJA-UHFFFAOYSA-N

Beschreibung

Application

Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs).

Biochem/physiol Actions

NNRTI (non-nucleoside reverse transcriptase inhibitor) of HIV-1

Nevirapine is an allosteric, non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI). The K_i for inhibition of wild-type RT by Nevirapine is 200 nM.

Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable