SMB00928

4′-Hydroxy carvedilol

• Synonym(e): 4′-Hydroxy carvedilol, 4′-Hydroxyphenyl carvedilol, 4′-OH carvedilol, 4′OH-CVD, 4-(2-(3-(9H-carbazol-4-yloxy)-2-hydroxypropylamino)ethoxy)-3-methoxyphenol, 4-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol, 4OHC, BM 140686, BM 14686, Carvedilol metabolite M4
• Empirische Formel (Hill-System): C₂₄H₂₆N₂O₅
• CAS-Nummer: 142227-49-4
• Molekulargewicht: 422.47
• UNSPSC Code: 12352200
• NACRES: NA.25

Eigenschaften

• assay: ≥95%
• Quality Segment: 100
• form: solid
• color: off-white to white
• storage temp.: 2-8°C
• SMILES string: [nH]1c2c(c4c1cccc4)c(ccc2)OCC(O)CNCCOc3c(cc(cc3)O)OC
• InChI: 1S/C24H26N2O5/c1-29-23-13-16(27)9-10-21(23)30-12-11-25-14-17(28)15-31-22-8-4-7-20-24(22)18-5-2-3-6-19(18)26-20/h2-10,13,17,25-28H,11-12,14-15H2,1H3
• InChI key: ZCJHEORDHXCJNB-UHFFFAOYSA-N

Beschreibung

General description

Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency.

Application

Metabolomics

Other Notes

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Sicherheitshinweise

• Piktogramme: GHS08,GHS09
• Signalwort: Warning
• Gefahrencodes: H373,H411
• Sicherheitshinweise: P260 - P273 - P314 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2 - STOT RE 2
• Zielorgane: Liver,spleen,Uterus (including cervix),Adrenal gland
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable