S4068

Splitomicin

≥98% (HPLC), powder

• Synonym(e): 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
• Empirische Formel (Hill-System): C₁₃H₁₀O₂
• CAS-Nummer: 5690-03-9
• Molekulargewicht: 198.22
• NACRES: NA.77
• PubChem Substance ID: 24724608
• UNSPSC Code: 12352200
• MDL number: MFCD08705254
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage temp.: 2-8°C
• SMILES string: O=C1CCc2c(O1)ccc3ccccc23
• InChI: 1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
• InChI key: ISFPDBUKMJDAJH-UHFFFAOYSA-N

Beschreibung

Application

Splitomicin was used to inhibit SIRT1 in human aortic endothelial cells[1][2] and sirtuins in human breast cancer cells.[3] Mouse leukaemic monocyte macrophage cell line was treated with Splitomicin prior to cholesterol efflux studies.[4]

Biochem/physiol Actions

Splitomicin, a derivative of β-naphthol is an inhibitor of Silent Information Regulator 2 (SIR2). It inhibits the NAD⁺-dependent deacetylase activity of Sir2 in vitro.PMID 19327818 It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca⁺² and ATP release. This results in inhibition of platelet aggregation that is effective in cardiovascular and cerebrovascular diseases.PMID 15189148

Sir2p (silent information regulator) and HDAC inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)